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Consistently, in a more recent meta-analysis of 40 randomized controlled trials performed in patients with T2DM, compared with standard diabetes therapies (i.e., metformin, sulfonylureas, insulin, DPP-4i, thiazolidinediones) and placebo, GLP-1RA therapy was associated with significant reductions in inflammatory markers such as serum C-reactive protein (CRP) and TNF-, and a significant increase in adiponectin [80]
E.Grey CloudL.LiuS.et al (2017)
Patients should place semaglutide in the refrigerator immediately upon receipt and avoid leaving it on countertops or in vehicles during transit or storage
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